Prior authorization automation leverages AI and robotic process automation to handle PA submissions, tracking, and appeals without manual staff intervention, reducing costs by approximately $34 per request and bringing denial rates below 5%. The technology integrates with EHR systems to automatically extract clinical data and submit requests through EDI 278 standards or payer APIs, eliminating the need for staff to manually navigate multiple payer portals. The CMS Interoperability and Prior Authorization Final Rule, effective January 2026, now requires payers to respond to PA requests within 72 hours for urgent cases and seven days for standard requests, making automation both a cost-reduction strategy and a compliance requirement.