Reactome Releases Two New AI-Focused Preprints

Reactome has released two preprints describing recent advances in applying artificial intelligence to pathway curation and user access. The preprint, Application of Large Language Models for Annotating Genes into Reactome Pathways , presents an LLM-assisted workflow that supports expert curators by identifying candidate pathways for genes, retrieving relevant literature, and generating mechanistic summaries. Evaluation shows that the approach can meaningfully support manual curation while preserving curator oversight.