Dengue Virus Infection New and Updated Topics and Pathways. Topics with new or revised pathways in this release include Disease ( Dengue virus infection , Diseases of urea cycle , Enterobacterial factors antagonize host defense , NS1-mediated effects on host pathways , and SARS-CoV-2 activates/modulates innate and adaptive immune responses ), Gene expression ( Epigenetic regulation of gene expression by MLL3 and MLL4 complexes and Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 ) Immune System ( GBP-mediated host defense ), Metabolism ( ATF6B (ATF6-beta) activates chaperones , Cho