Developmental Lineages of Integumentary System New and Updated Topics and Pathways. Topics with new or revised pathways in this release include Cell-Cell Communication ( Regulation of CDH1 Expression and Function ), Circadian clock ( BMAL1:CLOCK,NPAS2 activates circadian expression ), Developmental Biology ( Developmental Lineage of Mammary Gland Myoepithelial Cells , Developmental Lineage of Mammary Stem Cells , Developmental Lineages of the Mammary Gland ), Disease ( Infection with Enterobacteria , Loss of Function of KMT2D in Kabuki Syndrome ), Metabolism ( Cholesterol biosynthesis , Cytoch