New and Updated Topics and Pathways. Topics with new or revised pathways in this release include Autophagy ( Mitophagy ), Cell Cycle ( Meiotic recombination and Resolution of sister chromatid cohesion ); Developmental Biology ( MITF-M-regulation melanocyte development ); DNA Repair ( Resolution of D-loop structures through Holliday Junction Intermediates ); Gene Expression ( Regulation of endogenous retroelements ); Immune System ( SLC15A4:TASL-dependent IRF5 activation ); Metabolism ( Aerobic respiration and respiratory electron transport including Respiratory electron transport , Complex I b