Maternal to zygotic transition New and Updated Topics and Pathways. In V86, Topics with new or revised pathways include Cellular responses to stimuli ( KEAP1-NFE2L2 pathway ), Developmental biology ( Formation of anterior neural plate , Formation of posterior neural plate , and Maternal to zygotic transition (MZT) ), Immune system ( PKR-mediated signaling ), Metabolism ( Vitamin B5 (pantothenate) metabolism ), Metabolism of RNA ( Mitochondrial RNA degradation ), and Metabolism of proteins ( Protein hydroxylation ). New and Updated Illustrations.