Infectious Disease New and Updated Topics and Pathways. In V84, Topics with new or revised pathways include Developmental Biology ( Formation of definitive endoderm ), Gene Expression ( Formation of WDR5-containing histone-modifying complexes ), and Signal Transduction ( Regulation of TNFR1 signaling , TNFR1-induced NF-kappa-B signaling pathway , and TNFR1-induced proapoptotic signaling ). The Infectious disease pathway has been reorganized with grouping pathways for Bacterial Infection Pathways , Viral Infection Pathways , and Parasitic Infection Pathways .