Cytokine Signaling in Immune System New and Updated Topics and Pathways. In V83, Topics with new or revised pathways include Developmental Biology ( Formation of axial mesoderm , Formation of lateral plate mesoderm , Formation of paraxial mesoderm ), Immune System ( Signaling by CSF1 (M-CSF) in myeloid cells ), Metabolism ( Gluconeogenesis ), Metabolism of proteins ( Insulin processing ), Metabolism of RNA ( mRNA Splicing - Major Pathway ), Programmed Cell Death ( Regulation of necroptotic cell death ), Signal Transduction ( Regulation of TNFR1 signaling , TNFR1-induced NFkappaB signaling path