New and Updated Topics and Pathways. In V80, Topics with new or revised pathways include Cellular responses to stimuli ( Cellular response to chemical stress , Cytoprotection by HMOX1 , KEAP1-NFE2L2 pathway ), Disease ( Defective HDR through Homologous Recombination (HRR) Due to BRCA2 Loss of Function , Diseases of nucleotide metabolism , and SARS-CoV-2-host interactions ), DNA repair ( Presynaptic phase of homologous DNA pairing and strand exchange ), Drug ADME ( Atorvastatin ADME ), Metabolism ( Cobalamin (Cbl, vitamin B12) transport and metabolism ), and Metabolism of Proteins ( Neddylation