New and Updated Topics and Pathways. In V79 we have introduced the new topic Drug Absorption, Distribution, Metabolism and Excretion in which we cover both pharmacokinetics and pharmacodynamics of Aspirin , Azathioprine , and Paracetamol . Topics with new or revised pathways in this release include Cell Cycle ( Cyclin D associated events in G1 and Drug-mediated inhibition of CDK4/CDK6 activity ), DNA Replication ( Assembly of the pre-replicative complex ), Immune System ( Interferon alpha/beta signaling ), Metabolism ( Cholesterol biosynthesis and Choline catabolism ), and Sensory Perception (