New and Updated Topics and Pathways. Topics with new or revised pathways in V77 include Disease ( Defective HDR through Homologous Recombination (HRR) Due to PALB2 Loss of Function , Defective pyroptosis , Loss of Function of TP53 in Cancer , Maturation of nucleoprotein , and Signaling by ALK in cancer ), DNA repair ( Homologous DNA Pairing and Strand Exchange ), Programmed Cell Death ( Pyroptosis ), and Signal transduction ( Fc epsilon receptor (FCERI) signaling , RHOD GTPase Cycle , RHOF GTPase Cycle , RHOU GTPase Cycle , RHOV GTPase Cycle , and Signaling by ALK ). New and Updated Illustrati