Version 75 Released

New and Updated Pathways . Topics with new or revised pathways in release 75 include Developmental biology ( Transcriptional regulation of testis differentiation ), Disease ( Alternative lengthening of telomeres , Defective DNA double strand break response due to BARD1 loss of function , Defective DNA double strand break response due to BRCA1 loss of function , Signaling by FLT3 in disease ), DNA Repair ( Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks ), Immune system ( FLT3 signaling ), and Signal transduction ( RHOBTB GTPase cycle ).