New and Updated Pathways. In version 71, Topics with new or revised pathways include Autophagy ( Aggrephagy ), Cell Cycle ( EML4 and NUDC in mitotic spindle formation ), Cellular responses to external stimuli ( EIK2AK4 (GCN2) modifies gene expression in response to amino acid deficiency and Response of EIF2AK1 (HRI) to heme deficiency ), Disease ( Defective base excision repair associated with OGG1 , HCMV infection , Infection with Mycobacterium tuberculosis , and Signaling by ERBB2 in Cancer ), Generic transcription pathway ( Transcriptional regulation by VENTX ), Metabolism ( Metabolism of p