New and Updated Pathways. In version 70, topics with new or revised pathways include Cellular response to stress ( Amino acids regulate mTORC1 ), Disease ( Evasion of oncogene induced senescence due to p16-INK4A defects , Evasion of oxidative stress induced senescence due to p16-INK4A defects , Defective intrinsic pathway for apoptosis due to p14ARF loss of function , Evasion of oncogene induced senescence due to p14ARF defects , Evasion of oxidative stress induced senescence due to p14ARF defects ), Immune System ( Alpha-protein kinase 1 signaling pathway and FLT3 signaling ), and Signal tran