New and Updated Pathways. In version V69, Autophagy, including Chaperone Mediated Autophagy and Microautophagy is new. Topics with new or revised pathways include Development ( Transcriptional Regulation of Granulopoiesis ), Disease ( Evasion of Oncogene Induced Senescence Due to p16-INK4A Defects and Evasion of Oxidative Stress Induced Senescence Due to p16-INK4A Defects ), Immune system ( FLT3 Signaling ), and Signal Transduction ( Extra-Nuclear Estrogen Signaling and Signaling by ERBB4 ).