Towards the One Exposome: harnessing artificial intelligence and digital health technologies across One Health toxicology, new approach methodologies, and environmental public health

The One Exposome framework integrates exposomics, One Health toxicology, New Approach Methodologies (NAMs) and artificial intelligence to advance environmental health from reactive risk assessment towards predictive, preventive, and participatory science. The paper positions One Health as the ethical and conceptual rationale for recognizing the interdependence of human, animal, and environmental health, the Exposome as the framework for measuring cumulative and life-course exposures, and NAMs together with digital and AI-enabled tools as the means to generate, integrate, and interpret mechanis