Abstract This paper provides a multiple-methods analysis of an emerging domain of biosafety and bioscience scholarship—the intersection of biosecurity and Artificial Intelligence (AI), or BSxAI. Conducting both funding and genealogical analyses of the literature, we explore how this intersection came to be problematised, and the intellectual and financial sources mobilised in popularising the space. We argue that rather than constituting a conventional scientific domain, BSxAI is an area intentionally cultivated by a narrow range of funding bodies with particular ideological interests tied