Sample preparation is a critical step in any cell-based workflow, and its success is pivotal in determining the outcomes of downstream processes such as cell growth for patient-derived xenograft (PDX) models, CRISPR transduction efficiency, single-cell RNA sequencing, proteomics, and functional assays like cytokine release assays (Seahorse) or metabolomics studies (Isoplexis)1,2. At the heart of sample preparation lies cell separation, which needs to be thorough, removing all traces of dead or dying cells and debris, and gentle to preserve cell viability, cell representation, and integrity, al