This guide explains how OPC UA and MQTT complement each other in industrial data pipelines: OPC UA provides structured, secure access to machine data at the edge, while MQTT enables scalable distribution across enterprises and cloud systems. The article covers three bridging patterns — custom OPC UA clients publishing to MQTT, edge gateways with built-in adapters, and native OPC UA pub/sub over MQTT — along with design considerations for payload format, topic structure, and security continuity. Deployment scenarios span manufacturing, energy, and predictive maintenance industries.