Every enterprise conversation about artificial intelligence eventually arrives at the same uncomfortable question: what happens to our data once it leaves our perimeter? Whether you are wiring a large language model into a claims processing pipeline, standing up a retrieval-augmented generation (RAG) system for internal knowledge search, or letting an agentic workflow take autonomous actions against production systems, the answer determines whether your AI initiative becomes a competitive advantage or a compliance incident waiting to happen. This article lays out a layered, defense-in-depth ap