An mRNA-encoded masked IL-12 improves systemic tolerability while maintaining anti-tumor efficacy in preclinical studies

Kanchana Ravichandran, Erwan LeScolan, Na Cai, Bruce Howng, Robert Lau, Lisa Clark, Joshua Millet, Pankaj Kumar, Sushma Gurumurthy, Raghava Sriramaneni, Sean McAllister, Vangipuran Rangan, Olga Vasiljeva, Madan Paidhungat, Dylan Daniel, Marcia Belvin, Lin Guey. Presented at the American Association for Cancer Research Annual Meeting, April 28, 2025.