Engineering therapeutic peptides with 50% success rate under tight multi-property constraints, 5× faster than prior efforts

Scientists at a top-20 pharmaceutical company optimized three late-stage therapeutic peptide programs for a top-20 pharmaceutical partner, each requiring simultaneous optimization of potency, specificity, expression, and thermostability. Cradle generated libraries with a ≥50% success rate in matching all constraints while delivering significant potency improvements, completing in one round what the partner estimated would have required five rounds historically.