Rescuing a stalled IgG campaign: 10 candidates meeting potency and developability criteria in 3 rounds

Scientists at a top-50 pharmaceutical partner engineered an IgG for six developability properties (potency, aggregation, nonspecificity, cell binding, immunogenicity, expression) across three rounds. After prior screening and optimization efforts failed to produce candidates meeting both potency and developability criteria, CRADLE-1 delivered 10 successful candidates that advanced to the next pipeline stage.