Improving Staphylococcus aureus vaccine thermostability by 2.5 °C in a single round, 7× faster than rational design

Scientists at a top-20 pharmaceutical company optimized a chimeric Staphylococcus aureus vaccine antigen for thermostability in a single round. The best candidate achieved a 2.50 °C increase in melting temperature, completing in one round what the partner estimated would have required seven rounds via historical rational design approaches.