The importance of high analytical sensitivity and specificity of 5 and 6-base assays to enhance the detection of ctDNA in liquid biopsy applications

We investigated the impact of a duet single stranded ligation workflow on methylation LoD (further details on duet single stranded ligation workflow are provided in poster #121) across duet +modC (which provides 5-base data) and duet evoC (which provides 6-base data, distinguishing between 5mC and 5mC).