In this post, we provide practical guidance for designing applications that scale effectively with the Amazon Aurora DSQL distributed architecture. You will learn how to identify common patterns that limit scalability, apply proven design patterns that distribute workload efficiently, and implement transaction strategies optimized for Aurora DSQL. We cover primary key selection, schema design principles, indexing strategies, and multi-Region optimization, while maintaining full ACID (atomicity, consistency, isolation, and durability) compliance across AWS Regions.