Key Takeaways Quick Answer: What Is the Best Certificate Lifecycle Management Software? Certificate lifecycle management software automates the discovery, issuance, renewal, rotation, and revocation of digital certificates across an organization’s environments. The leading options in 2026 are Venafi (CyberArk), Keyfactor, DigiCert, AppViewX, Sectigo, Entrust, HashiCorp Vault, and Akeyless.